Pramipexole versus ropinirole: Polysomnographic acute effects in restless legs syndrome
Identifieur interne : 001460 ( Main/Exploration ); précédent : 001459; suivant : 001461Pramipexole versus ropinirole: Polysomnographic acute effects in restless legs syndrome
Auteurs : Mauro Manconi [Italie, Suisse] ; Raffaele Ferri [Italie] ; Marco Zucconi [Italie] ; Alessandro Oldani [Italie] ; Laura Giarolli [Italie] ; Valentina Bottasini [Italie] ; Luigi Ferini-Strambi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Antiparkinson Agents (therapeutic use), Benzothiazoles (therapeutic use), Comparative study, Double-Blind Method, Female, Humans, Indoles (therapeutic use), Male, Middle Aged, Nervous system diseases, Polysomnography, Polysomnography (methods), Pramipexole, Prospective Studies, Restless Legs Syndrome (drug therapy), Restless legs syndrome, Ropinirole, Statistics as Topic, periodic leg movements, polysomnography, pramipexole, restless legs syndrome, ropinirole.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Benzothiazoles, Indoles.
- drug therapy : Restless Legs Syndrome.
- methods : Polysomnography.
- Adult, Aged, Analysis of Variance, Double-Blind Method, Female, Humans, Male, Middle Aged, Prospective Studies, Statistics as Topic.
Abstract
Background: Pramipexole and ropinirole have become the first‐line treatment for restless legs syndrome. The aim of this study was to perform the first direct comparison between these two molecules in restless legs syndrome. Methods: A double‐blind, placebo‐controlled, double‐night and prospective investigation was carried out in 45 consecutive naïve patients with idiopathic restless legs syndrome. Each patient underwent two consecutive full‐night polysomnographies: the first baseline recording was performed without premedication and, before the second recording, first group received a single oral dose of 0.25 mg pramipexole, second group a single oral dose of 0.5 mg ropinirole, and the remaining patients received placebo. Results and Discussion: Both dopamine agonists improved restless legs syndrome symptoms and markedly suppressed periodic leg movements during sleep compared to placebo, without significant differences between pramipexole and ropinirole. No significant side effects, except for mild morning nausea (2 patients treated with ropinirole, 3 with pramipexole, and 1 with placebo), were reported. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23543
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Background: Pramipexole and ropinirole have become the first‐line treatment for restless legs syndrome. The aim of this study was to perform the first direct comparison between these two molecules in restless legs syndrome. Methods: A double‐blind, placebo‐controlled, double‐night and prospective investigation was carried out in 45 consecutive naïve patients with idiopathic restless legs syndrome. Each patient underwent two consecutive full‐night polysomnographies: the first baseline recording was performed without premedication and, before the second recording, first group received a single oral dose of 0.25 mg pramipexole, second group a single oral dose of 0.5 mg ropinirole, and the remaining patients received placebo. Results and Discussion: Both dopamine agonists improved restless legs syndrome symptoms and markedly suppressed periodic leg movements during sleep compared to placebo, without significant differences between pramipexole and ropinirole. No significant side effects, except for mild morning nausea (2 patients treated with ropinirole, 3 with pramipexole, and 1 with placebo), were reported. © 2011 Movement Disorder Society</div>
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